Role of immunoreactive patterns of lymph nodes in neck dissection cases of oral squamous cell carcinoma: a clinical and histopathological study
Bhatlawande Harshada C., Kale Alka D., Desai Karishma M., Hallikerimath Seema, Belaldavar Chetan, Mane Deepa, Angadi Punnya V., Manjula M., Muttagi Sidramesh,
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( Bhatlawande Harshada C. ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Kale Alka D. ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Desai Karishma M. ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Hallikerimath Seema ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Belaldavar Chetan ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Mane Deepa ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Angadi Punnya V. ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Manjula M. ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral Pathology and Microbiology
( Muttagi Sidramesh ) - KLE University KLE VK Institute of Dental Sciences and Hospital Department of Oral and Maxillofacial Surgery
Abstract
Objectives: Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC.
Materials and Methods: Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated.
Results: The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia ( P =0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade.
Conclusion: The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.
키워드
Lymph node; Lymphatic metastasis; Squamous cell carcinoma; Neck dissection; Germinal center
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